ginsenoside 20 ( R ) -Rg3
It is the 20 ( R ) epimer of ginsenoside 20 ( S ) -Rg3
R 1 = -Glc 2-1 Glc
R2 = H
- Gssd. 20 ( R ) Rg 3 as well as its 20 ( S ) epimer causes relaxation of intact endothelial porcine coronary artery strips following a previous contraction of 3 μM serotonin. ( Kim2006seg )
- Gssd. 20 ( R ) Rg 3 , unlike the 20 ( S ) epimer, does not have an endothelium-independent relaxation effect on the blood vessel (coronary artery strips) contracted with 25 mM KCl. ( Kim2006seg )
- Stereospecificity: gssd. 20 ( R ) Rg 3 does not show the same effects on Ca 2+ , K + and Na + ion channels as its 20 ( S ) epimer . However, both epimers inhibit the serotonin 5HT 3A receptor and the? 3? 4 nicotinic acetylcholine receptor. ( Jeong2004sgr )